P2X7 receptor isoforms and neuroblastoma: the key role of P2X7B in drug resistance (2022)
- Authors:
- Autor USP: SAMPAIO, VANESSA FERNANDES ARNAUD - IQ
- Unidade: IQ
- Sigla do Departamento: QBQ
- DOI: 10.11606/T.46.2022.tde-10082023-115821
- Subjects: NEOPLASIAS; CÉLULAS-TRONCO; NEUROBLASTOMA
- Keywords: Câncer infantil; Cancer stem cells; Células-tronco tumorais; Chemoresistance; Childhood cancer; Epithelial-mesenchymal transition; Isoforma P2X7B; P2X7 receptor; P2X7B isoform; Quimiorresistência; Receptor P2X7; Transição epitélio-mesenquimal
- Agências de fomento:
- Language: Inglês
- Abstract: Drug resistance is a major challenge for all oncological treatments that involve the use of cytotoxic agents. Recent therapeutic alternatives cannot circumvent the ability of cancer cells to adapt or alter the natural selection of resistant cells, so the problem persists. In neuroblastoma, recurrence can occur in 50% of high-risk patients. Therefore, the identification of novel therapeutic targets capable of modulating survival or death following classical antitumor interventions is crucial to address this problem. In this study, we investigated the role of the P2X7 receptor in chemoresistance. Here, we elucidated the contributions of P2X7 receptor A and B isoforms to neuroblastoma chemoresistance, demonstrating that the B isoform favors resistance through a combination of mechanisms including drug efflux via MRP-type transporters, resistance to retinoids, retaining cells in a stem-like phenotype, suppression of autophagy, and EMT induction, while the A isoform has opposite and/or complementary roles
- Imprenta:
- Data da defesa: 15.12.2022
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by-nc-sa
-
ABNT
SAMPAIO, Vanessa Fernandes Arnaud. P2X7 receptor isoforms and neuroblastoma: the key role of P2X7B in drug resistance. 2022. Tese (Doutorado) – Universidade de São Paulo, São Paulo, 2022. Disponível em: https://www.teses.usp.br/teses/disponiveis/46/46131/tde-10082023-115821/. Acesso em: 23 maio 2024. -
APA
Sampaio, V. F. A. (2022). P2X7 receptor isoforms and neuroblastoma: the key role of P2X7B in drug resistance (Tese (Doutorado). Universidade de São Paulo, São Paulo. Recuperado de https://www.teses.usp.br/teses/disponiveis/46/46131/tde-10082023-115821/ -
NLM
Sampaio VFA. P2X7 receptor isoforms and neuroblastoma: the key role of P2X7B in drug resistance [Internet]. 2022 ;[citado 2024 maio 23 ] Available from: https://www.teses.usp.br/teses/disponiveis/46/46131/tde-10082023-115821/ -
Vancouver
Sampaio VFA. P2X7 receptor isoforms and neuroblastoma: the key role of P2X7B in drug resistance [Internet]. 2022 ;[citado 2024 maio 23 ] Available from: https://www.teses.usp.br/teses/disponiveis/46/46131/tde-10082023-115821/ - P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma
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Informações sobre o DOI: 10.11606/T.46.2022.tde-10082023-115821 (Fonte: oaDOI API)
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