Multiparameter optimization of Trypanocidal cruzain inhibitors with in vivo activity and favorable pharmacokinetics (2022)
- Authors:
- Pauli, Ivani
- Rezende Junior, Celso de Oliveira - Universidade Estadual de Campinas (UNICAMP)
- Slafer, Brian W. - Universidade Estadual de Campinas (UNICAMP)
- Dessoy, Marco A. - Universidade Estadual de Campinas (UNICAMP)
- Souza, Mariana Laureano de
- Ferreira, Leonardo Luiz Gomes
- Adjanohun, Abraham L. M. - Universidade Federal de Minas Gerais (UFMG)
- Ferreira, Rafaela S. - Universidade Federal de Minas Gerais (UFMG)
- Magalhães, Luma Godoy
- Andricopulo, Renata Krogh
- Duarte, Simone Michelan
- Del Pintor, Ricardo Vaz - Universidade Federal de São Paulo (UNIFESP)
- Silva, Fernando B. R. da - Universidade Federal de São Paulo (UNIFESP)
- Cruz, Fabio C. - Universidade Federal de São Paulo (UNIFESP)
- Dias, Luiz C. - Universidade Estadual de Campinas (UNICAMP)
- Andricopulo, Adriano Defini
- USP affiliated authors: ANDRICOPULO, ADRIANO DEFINI - IFSC ; ANDRICOPULO, RENATA KROGH - IFSC ; DUARTE, SIMONE MICHELAN - IFSC ; PAULI, IVANÍ - IFSC ; SOUZA, MARIANA LAUREANO DE - IFSC ; FERREIRA, LEONARDO LUIZ GOMES - IFSC ; MAGALHÃES, LUMA GODOY - IFSC
- Unidade: IFSC
- DOI: 10.3389/fphar.2021.774069
- Subjects: DOENÇA DE CHAGAS; TRYPANOSOMA CRUZI; QUÍMICA MÉDICA; MODELAGEM MOLECULAR; PLANEJAMENTO DE FÁRMACOS
- Keywords: Chagas disease; Cruzain; Medicinal chemistry; Drug design; Multiparameter optimization; Pharmacokinetics; Molecular modeling
- Agências de fomento:
- Language: Inglês
- Imprenta:
- Source:
- Título do periódico: Frontiers in Pharmacology
- ISSN: 1663-9812
- Volume/Número/Paginação/Ano: v. 12, p. 774069-1-774069-21 + supplementary material, Jan. 2022
- Este periódico é de acesso aberto
- Este artigo é de acesso aberto
- URL de acesso aberto
- Cor do Acesso Aberto: gold
- Licença: cc-by
-
ABNT
PAULI, Ivani et al. Multiparameter optimization of Trypanocidal cruzain inhibitors with in vivo activity and favorable pharmacokinetics. Frontiers in Pharmacology, v. 12, n. Ja 2022, p. 774069-1-774069-21 + supplementary material, 2022Tradução . . Disponível em: https://doi.org/10.3389/fphar.2021.774069. Acesso em: 23 maio 2024. -
APA
Pauli, I., Rezende Junior, C. de O., Slafer, B. W., Dessoy, M. A., Souza, M. L. de, Ferreira, L. L. G., et al. (2022). Multiparameter optimization of Trypanocidal cruzain inhibitors with in vivo activity and favorable pharmacokinetics. Frontiers in Pharmacology, 12( Ja 2022), 774069-1-774069-21 + supplementary material. doi:10.3389/fphar.2021.774069 -
NLM
Pauli I, Rezende Junior C de O, Slafer BW, Dessoy MA, Souza ML de, Ferreira LLG, Adjanohun ALM, Ferreira RS, Magalhães LG, Andricopulo RK, Duarte SM, Del Pintor RV, Silva FBR da, Cruz FC, Dias LC, Andricopulo AD. Multiparameter optimization of Trypanocidal cruzain inhibitors with in vivo activity and favorable pharmacokinetics [Internet]. Frontiers in Pharmacology. 2022 ; 12( Ja 2022): 774069-1-774069-21 + supplementary material.[citado 2024 maio 23 ] Available from: https://doi.org/10.3389/fphar.2021.774069 -
Vancouver
Pauli I, Rezende Junior C de O, Slafer BW, Dessoy MA, Souza ML de, Ferreira LLG, Adjanohun ALM, Ferreira RS, Magalhães LG, Andricopulo RK, Duarte SM, Del Pintor RV, Silva FBR da, Cruz FC, Dias LC, Andricopulo AD. Multiparameter optimization of Trypanocidal cruzain inhibitors with in vivo activity and favorable pharmacokinetics [Internet]. Frontiers in Pharmacology. 2022 ; 12( Ja 2022): 774069-1-774069-21 + supplementary material.[citado 2024 maio 23 ] Available from: https://doi.org/10.3389/fphar.2021.774069 - Structure-based and molecular modeling studies for the discovery of cyclic imides as reversible cruzain inhibitors with potent anti-Trypanosoma cruzi activity
- Discovery of potent, reversible, and competitive cruzain inhibitors with trypanocidal activity: a structure-based drug design approach
- Carbamoylimidazoles as potent cruzain inhibitors with in vitro and in vivo trypanocidal activity: a structure-based drug design approach
- Antitrypanosomal aminobenzimidazoles: hit to lead expansion of new chemical entities against Trypanosoma cruzi and Leishmania infantum
- SAR studies on a series of reversible competitive inhibitors of cruzain from Trypanosoma cruzi
- Indoles hit-to-lead for chagas disease: lessons learned within the LOLA consortium
- Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids
- Synthesis and anti-trypanosoma cruzi activity of 3-cyanopyridine derivatives
- Antitrypanosomal Benzoxazinone series: hit-to-lead campaign and multiparametric optimization
- Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum
Informações sobre o DOI: 10.3389/fphar.2021.774069 (Fonte: oaDOI API)
Download do texto completo
Tipo | Nome | Link | |
---|---|---|---|
PROD032730_3062985.pdf | Direct link |
How to cite
A citação é gerada automaticamente e pode não estar totalmente de acordo com as normas