Artigo de periodico

Association between the timing of maternal vaccination and newborns? anti-pertussis toxin antibody levels (2019)

• Authors:
  • Vaz de Lima, Lourdes Rehder de Andrade
  • Castilho, Euclides A. de
  • Sato, Helena Keico
  • Fernandes, Eder Gatti
  • Sato, Ana Paula Sayuri
  • Pawloski, Lúcia C
  • Tondella, Maria Lúcia
  • Brito, Cyro A. de
  • Luna, Expedito José de Albuquerque
  • Carvalhanas, Telma Regina M.P
• USP affiliated authors: CASTILHO, EUCLIDES AYRES DE - FM ; SATO, ANA PAULA SAYURI - FSP ; LUNA, EXPEDITO JOSÉ DE ALBUQUERQUE - IMT
• Unidades: FM; FSP; IMT
• DOI: 10.1016/j.vaccine.2019.04.079
• Subjects: SAÚDE MATERNO-INFANTIL; COQUELUCHE; VACINAÇÃO; ANTICORPOS
• Agências de fomento:
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
    Processo FAPESP: 2015/16157-1
• Language: Inglês
• Abstract: Background:Pertussis remains an important global public health concern, despite the presence of exten-sive immunization programs. Incidence and severity of pertussis are typically higher in neonates andyoung infants. As a strategy to protect these young infants, maternal vaccination with Tdap (tetanus tox-oid, reduced diphtheria toxoid, and acellular pertussis) has been recommended in Brazil. The objective ofthis study was to evaluate the effects of Tdap vaccination during pregnancy on the anti-pertussis toxin(PT) IgG response in mothers and their infants at birth.Material and methods:Maternal and cord blood samples were collected from vaccinated (n = 243) andunvaccinated (n = 75) pregnant women, at the time of delivery, from July 2015 to August 2016 in SãoPaulo, Brazil. Anti-PT IgG antibodies were quantified by Enzyme-Linked Immunosorbent Assay (ELISA)and geometric mean concentrations (GMC) were calculated. Relationship between timing of vaccinationand antibody concentrations were evaluated.Results:Maternal and cord blood GMCs among the vaccinated group were 5.4 and 5.6 fold higher [66.5International Units (IU)/mL and 89.8 IU/mL] compared to the unvaccinated group (12.4 IU/mL and16.1 IU/mL), respectively (p < 0.001). Higher anti-PT IgG GMCs were observed when vaccination occurred 60 days before delivery compared to <60 days, suggesting that vaccination early in the third trimestermay be more effective than later in pregnancy.Conclusion:Tdap maternal vaccination results in significantly higher anti-PT IgG in newborn infants andsupports the current recommendation of the Brazilian Immunization Program
• Imprenta:
  • Publisher place: Amsterdam
  • Date published: 2019
• Source:
  • Título do periódico: Vaccine
  • ISSN: 0264-410X
  • Volume/Número/Paginação/Ano: v.37, n.36, p.5474-5480, 2019

Informações sobre o DOI: 10.1016/j.vaccine.2019.04.079 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo é de acesso aberto
• URL de acesso aberto
• Cor do Acesso Aberto: green

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How to cite

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• ABNT

  VAZ DE LIMA, Lourdes Rehder de Andrade et al. Association between the timing of maternal vaccination and newborns? anti-pertussis toxin antibody levels. Vaccine, v. 37, n. 36, p. 5474-5480, 2019Tradução . . Disponível em: https://doi.org/10.1016/j.vaccine.2019.04.079. Acesso em: 23 maio 2024.

• APA

  Vaz de Lima, L. R. de A., Castilho, E. A. de, Sato, H. K., Fernandes, E. G., Sato, A. P. S., Pawloski, L. C., et al. (2019). Association between the timing of maternal vaccination and newborns? anti-pertussis toxin antibody levels. Vaccine, 37( 36), 5474-5480. doi:10.1016/j.vaccine.2019.04.079

• NLM

  Vaz de Lima LR de A, Castilho EA de, Sato HK, Fernandes EG, Sato APS, Pawloski LC, Tondella ML, Brito CA de, Luna EJ de A, Carvalhanas TRMP. Association between the timing of maternal vaccination and newborns? anti-pertussis toxin antibody levels [Internet]. Vaccine. 2019 ;37( 36): 5474-5480.[citado 2024 maio 23 ] Available from: https://doi.org/10.1016/j.vaccine.2019.04.079

• Vancouver

  Vaz de Lima LR de A, Castilho EA de, Sato HK, Fernandes EG, Sato APS, Pawloski LC, Tondella ML, Brito CA de, Luna EJ de A, Carvalhanas TRMP. Association between the timing of maternal vaccination and newborns? anti-pertussis toxin antibody levels [Internet]. Vaccine. 2019 ;37( 36): 5474-5480.[citado 2024 maio 23 ] Available from: https://doi.org/10.1016/j.vaccine.2019.04.079

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