Artigo de periodico

Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement (2019)

• Authors:
  • Gomes, Juliana C
  • Cianni, Lorenzo
  • Ribeiro, Jean
  • Rocho, Fernanda dos Reis
  • Silva, Samelyn da Costa Martins
  • Batista, Pedro Henrique J
  • Moraes, Carolina Borsoi
  • Franco, Caio Haddad
  • Freitas Junior, Lúcio H G
  • Kenny, Peter W
  • Leitão, Andrei
  • Burtoloso, Antonio Carlos Bender
  • Vita, Daniela de
  • Montanari, Carlos Alberto
• USP affiliated authors: LEITÃO, ANDREI - IQSC ; BURTOLOSO, ANTONIO CARLOS BENDER - IQSC ; MONTANARI, CARLOS ALBERTO - IQSC ; GOMES, JULIANA CRISTINA - IQSC ; CIANNI, LORENZO - IQSC ; RIBEIRO, JEAN FRANCISCO ROSA - IQSC ; ROCHO, FERNANDA DOS REIS - IQSC ; SILVA, SAMELYN DA COSTA MARTINS - IQSC ; BATISTA, PEDRO HENRIQUE JATAI - IQSC ; FRANCO, CAIO HADDAD - ICB ; VITA, DANIELA DE - IQSC
• Unidades: IQSC; ICB
• DOI: 10.1016/j.bmc.2019.115083
• Assunto: QUÍMICA
• Keywords: Covalent inhibitor; Cruzain; Covalent inhibitorCruzainCysteine proteaseGroup efficiencyLipophilic efficiencyNon-additivityStructure-activity relationship; Cysteine protease
• Agências de fomento:
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
    Processo FAPESP: 2016/07946-5
• Language: Inglês
• Imprenta:
  • Publisher place: Oxford
  • Date published: 2019
• Source:
  • Título do periódico: Bioorganic and Medicinal Chemistry
  • ISSN: 0968-0896
  • Volume/Número/Paginação/Ano: v. 27, n. 22, p.x 115083, nov, 2019

Informações sobre o DOI: 10.1016/j.bmc.2019.115083 (Fonte: oaDOI API)
• Este periódico é de assinatura
• Este artigo NÃO é de acesso aberto
  
• Cor do Acesso Aberto: closed

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• ABNT

  GOMES, Juliana C et al. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. Bioorganic and Medicinal Chemistry, v. 27, n. 22, p. x 115083, 2019Tradução . . Disponível em: https://doi.org/10.1016/j.bmc.2019.115083. Acesso em: 23 maio 2024.

• APA

  Gomes, J. C., Cianni, L., Ribeiro, J., Rocho, F. dos R., Silva, S. da C. M., Batista, P. H. J., et al. (2019). Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. Bioorganic and Medicinal Chemistry, 27( 22), x 115083. doi:10.1016/j.bmc.2019.115083

• NLM

  Gomes JC, Cianni L, Ribeiro J, Rocho F dos R, Silva S da CM, Batista PHJ, Moraes CB, Franco CH, Freitas Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, Vita D de, Montanari CA. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement [Internet]. Bioorganic and Medicinal Chemistry. 2019 ; 27( 22): x 115083.[citado 2024 maio 23 ] Available from: https://doi.org/10.1016/j.bmc.2019.115083

• Vancouver

  Gomes JC, Cianni L, Ribeiro J, Rocho F dos R, Silva S da CM, Batista PHJ, Moraes CB, Franco CH, Freitas Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, Vita D de, Montanari CA. Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement [Internet]. Bioorganic and Medicinal Chemistry. 2019 ; 27( 22): x 115083.[citado 2024 maio 23 ] Available from: https://doi.org/10.1016/j.bmc.2019.115083

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