Nonsyndromic cleft palate: phenotypes, familial recurrence and gestational history (2017)
- Authors:
- USP affiliated authors: SANTOS, CARLOS FERREIRA DOS - FOB ; NEVES, LUCIMARA TEIXEIRA DAS - FOB
- Unidade: FOB
- Subjects: FISSURA LÁBIOPALATINA; EVOLUÇÃO FENOTÍPICA; HEREDITARIEDADE; RECIDIVA
- Language: Inglês
- Abstract: Objectives: To investigate and describe the phenotype variations for nonsyndromic cleft palate (CP), also the genetic factors related to recurrence through family history and environmental factors by means of gestational history. Methods and Results: This retrospective study analyzed 165 medical records of individuals with isolated nonsyndromic CP registered at the Hospital for Rehabilitation of Craniofacial Anomalies (HRAC-USP). Females were majority with 106 cases (64.24%) and the predominant type of CP was incomplete corresponding to 88.48% of the total sample, and among these incomplete CP, the clefts involving partial hard palate were the most prevalent. A small group (n=5) presented a phenotype variation little known. Familial recurrence was observed in 28.47% of 144 cases where information was available and in most cases there was only one other affected family member. The average age of mothers and fathers at conception was 26.9 and 31.4 years respectively. The percentage of previous abortions was 11.95% of the 92 reported cases and parental consanguinity was found in 3.29% of the 91 reported cases. The most frequently gestational intercurrence reported was the consumption of medication during pregnancy (25 in 154 reported cases). Conclusion: In this investigated group with nonsyndromic CP, the most common phenotype was incomplete CP (partial hard palate), and a small group presented a different phenotype variation. The percentage of familial recurrence was considerable. The consumption of medication during the pregnancy and the prevalence of the previous abortions were the data that called more attention in the gestational history.
- Imprenta:
- Publisher: Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo
- Publisher place: Bauru
- Date published: 2017
- Source:
- Título do periódico: Anais
- Conference titles: Simpósio Internacional de Fissuras Orofaciais e Anomalias Relacionadas
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ABNT
GARBIERI, Thais Francini et al. Nonsyndromic cleft palate: phenotypes, familial recurrence and gestational history. 2017, Anais.. Bauru: Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo, 2017. Disponível em: https://repositorio.usp.br/directbitstream/7161165d-8518-4f91-a07d-07e8503edee7/2938676.pdf. Acesso em: 04 jun. 2024. -
APA
Garbieri, T. F., Mateo-Castillo, J. F., Santos, C. F. dos, & Neves, L. T. das. (2017). Nonsyndromic cleft palate: phenotypes, familial recurrence and gestational history. In Anais. Bauru: Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo. Recuperado de https://repositorio.usp.br/directbitstream/7161165d-8518-4f91-a07d-07e8503edee7/2938676.pdf -
NLM
Garbieri TF, Mateo-Castillo JF, Santos CF dos, Neves LT das. Nonsyndromic cleft palate: phenotypes, familial recurrence and gestational history [Internet]. Anais. 2017 ;[citado 2024 jun. 04 ] Available from: https://repositorio.usp.br/directbitstream/7161165d-8518-4f91-a07d-07e8503edee7/2938676.pdf -
Vancouver
Garbieri TF, Mateo-Castillo JF, Santos CF dos, Neves LT das. Nonsyndromic cleft palate: phenotypes, familial recurrence and gestational history [Internet]. Anais. 2017 ;[citado 2024 jun. 04 ] Available from: https://repositorio.usp.br/directbitstream/7161165d-8518-4f91-a07d-07e8503edee7/2938676.pdf - Fissura labiopalatina e agenesia dentária: investigação de polimorfismo no MSX1
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